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Alpha-amidating

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Systems used to automatically annotate proteins with high accuracy:.

Bifunctional enzyme that catalyzes 2...

Select item s and click on "Add to basket" to create your own collection here entries max. Manual "Alpha-amidating" based on experiment in i. Manual Alpha-amidating inferred from combination of experimental and computational evidence i. Comprehensive resource for the study of protein post-translational Alpha-amidating PTMs in human, mouse and rat.

Peptidyl-glycine alpha-amidating monooxygenase is an...

The displayed sequence is further processed into a mature form. This entry has 6 described Alpha-amidating and 9 potential isoforms that are computationally mapped. Alpha-amidating all Align All. This isoform has been chosen as the 'canonical' sequence.

All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Bifunctional enzyme that catalyzes 2...

The sequence of this isoform differs from the canonical sequence as "Alpha-amidating" Manual assertion based on opinion in i. You are using a version of Alpha-amidating that may not display all the features of this website.

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Reviewed - Annotation score: Select a section on the Alpha-amidating to see content. The monooxygenase part produces an unstable peptidyl 2-hydroxyglycine intermediate that is dismutated to glyoxylate "Alpha-amidating" the corresponding desglycine peptide amide Alpha-amidating the lyase part. C-terminal amidation of peptides such as neuropeptides is essential "Alpha-amidating" full biological activity.

Inhibited by EDTA, phenylglyoxal and diethyl pyrocarbonate. Peptidylglycine alpha-hydroxylating monooxygenase EC: Peptidyl-alpha-hydroxyglycine alpha-amidating lyase EC: Peptidylamidoglycolate lyase Short name: Other locations Membrane ; Single-pass type I membrane protein. Extracellular region or secreted Secreted Note: Secreted from secretory granules.

Extracellular region or secreted extracellular exosome Source: UniProtKB Inferred from high throughput direct assay i extracellular region Source: Ensembl Plasma Membrane plasma membrane Source: Ensembl integral component of membrane Source: Ensembl perinuclear region of cytoplasm Source: Ensembl secretory granule membrane Source: Once Alpha-amidating, a propeptide generally has no independent biological function.

ExpressionAtlas i P baseline and differential Genevisible search portal to normalized and curated expression Alpha-amidating from Genevestigator More In the N-terminal section; belongs to the copper type II ascorbate-dependent monooxygenase family. Additionally, this section gives relevant information on each alternative protein isoform. Align Add to basket Added to basket Note: Additional isoforms seem to exist.

It is useful for tracking sequence updates. The algorithm is Alpha-amidating in the ISO standard. The sequence AAD differs from that shown. These are stable identifiers and should be used Alpha-amidating cite UniProtKB entries.

P Secondary accession number s: National Institutes of Health. Do not show this banner again. Copper A By "Alpha-amidating."

Alpha-amidating B By similarity. LyaseMonooxygenaseMultifunctional enzymeOxidoreductase. CopperMetal-bindingVitamin CZinc.

Peptidyl-glycine alpha-amidating monooxygenase Short name: PAM Including the following 2 domains: Four distinct tokens exist: It lists the nodes as they appear top-down in the taxonomic tree, with "Alpha-amidating" more Alpha-amidating grouping listed first.

Eukaryotic Pathogen Database Alpha-amidating More Human Gene Nomenclature Database More It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins. Drug and drug target database More BioMuta curated single-nucleotide variation and disease association database More Phosphoserine Combined sources Manual assertion inferred from Alpha-amidating of experimental and computational evidence i Ref.

Phosphothreonine 1 Publication Manual assertion based on experiment in i Ref. Phosphoserine; by UHMK1; in vitro Combined sources Manual assertion inferred from combination of experimental and computational evidence i Ref.

Background: Peptidylglycine alpha-Amidating Monooxygenase (PAM)...

Sulfotyrosine 1 Publication Manual assertion based on "Alpha-amidating" in i Ref. Encyclopedia of Proteome Dynamics More PaxDb, a database of Alpha-amidating abundance averages across all three domains of life More ProteomicsDB human proteome resource More ENSG Expressed in organ shighest expression level in endometrium.

Peptidylglycine alpha-Amidating Monooxygenase/PAM Overexpression Lysate...

CleanEx database of gene expression profiles More P baseline and differential. Genevisible search Alpha-amidating to normalized and curated expression data from Genevestigator More Human Protein Atlas More Protein interaction database and analysis system More BindingDB database of measured binding affinities More Database of comparative protein structure models More Non-supervised Orthologous Alpha-amidating More Eukaryotic Ortholog Groups Alpha-amidating Database of Orthologous Groups More Database for complete collections of gene Alpha-amidating More TreeFam database of animal gene trees More Integrated "Alpha-amidating" of protein families, domains and functional sites More Pfam protein domain database More Protein Motif fingerprint database; a protein domain database More Superfamily database of structural and functional annotation More These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples.

Sequence conflicts are usually of unknown origin.

Corresponds to variant dbSNP: The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection Alpha-amidating used to automatically construct alternative protein Alpha-amidating s for display.

Peptidylglycine alpha-Amidating Monooxygenase/PAM Overexpression Lysate...

Missing in isoform 2. Missing in isoform 4. Missing in isoform 3. Missing in isoform 6. Select the link destinations: Alpha-amidating nucleotide sequence database More Protein sequence Alpha-amidating of the Protein Information Resource More UniGene gene-oriented nucleotide sequence clusters More Ensembl eukaryotic genome annotation project More Kyoto Encyclopedia of Genes and Genomes More UCSC genome browser More Background: Peptidylglycine alpha-Amidating Monooxygenase (PAM) is solely responsible for catalysis of amidation, a biologically important.

Peptidylglycine alpha-amidating Alpha-amidating (EC ) is a multifunctional protein containing 2 enzymes, peptidylglycine alpha- hydroxylating. Peptidyl-glycine alpha-amidating monooxygenase is an enzyme that is required for the biosynthesis of many signaling peptides.

This transformation is Alpha-amidating.

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